Pompe disease is a glycogen storage disorder characterized by a deficiency of the lysosomal enzyme acid-alpha glucosidase. There are three types of Pompe disease: infantile-onset, non-classic infantile-onset, and late-onset. The infantile-onset is the classic form where symptoms begin a few months after birth. Affected infants present with myopathy, hypotonia, hepatomegaly, and heart defects. They are usually described as “floppy”, have difficulty feeding, and fail to thrive. If left untreated, death from heart failure occurs in the first year of life. Late-onset Pompe disease is defined onset before age 12 months without cardiomyopathy and all individuals with onset after age 12 months. Pompe disease is estimated to affect 1 in 40,000 individuals in the United States and varies among different ethnic groups.