Medium-chain acyl-CoA dehydrogenase deficiency is a disease that prevents the body from burning certain fats for energy. The age of onset is typically in infancy, and symptoms include vomiting, lethargy, and hypoglycemia. The disease has also increased the risk of seizures, breathing difficulties, liver problems, brain damage, coma, and sudden death. This disease can be managed by a strict diet and avoiding periods of fasting. The incidence of medium-chain acyl-CoA dehydrogenase deficiency is estimated to be ~ 1 in 17,000.